منابع مشابه
Targeting PI3Kδ
We have recently uncovered the indispensable role of phosphoinositide-3-kinase δ (PI3Kδ) at different stages of the canonical killing pathway of cytotoxic T lymphocytes (CTLs). The interception of PI3Kδ-conveyed signals has been considered a valuable therapeutic strategy in oncology. However, our observations predict that the benefits of this approach may be limited by a trade-off between direc...
متن کاملPI3Kδ is indispensable for CTL-mediated cytotoxicity
Background The expression of catalytic phosphoinositol-3-kinase isoform δ (PI3Kδ) is restricted to the haematopoetic compartment. Accordingly, PI3Kδ serves as a drug target to eliminate leukaemic cells. However, we previously showed that PI3Kδ is indispensable for the function of natural killer (NK)-cells [1]. Thus, the therapeutic success of PI3Kδ inhibitors is likely to be compromised by unin...
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The diagnosis and nosology of Psychotic disorders have been matters of interest and debate since Kraeplin 's original delineation of Manic depressive illness and schizophrenia. Although in the past, it was largely of academic interset, the accurate classification of these disorders has assumed greater importance with the availability of newer and more specific treatments for the psychoses. Abou...
متن کاملIdelalisib: targeting PI3Kδ in B-cell malignancies.
Idelalisib—a fi rst-in-class selective inhibitor of phosphoinositide-3kinase delta, which is expressed only in haemopoietic cells—has been shown to be eff ective for treatment of B-cell malignancies in two clinical trials. First, in a single-group phase 2 study, researchers enrolled 125 patients with refractory, indolent non-Hodgkin lymphoma. Idelalisib (150 mg orally, twice daily) induced an o...
متن کاملMate choice turns cognitive.
Evolutionary psychology has revolutionized research on human mate choice and sexual attraction in recent years, combining a rigorous Darwinian framework based on sexual selection theory with a loosely cognitivist orientation to task analysis and mechanism modelling. This hard Darwinian, soft computational approach has been most successful at revealing the adaptive logic behind physical beauty, ...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2012
ISSN: 1945-3477
DOI: 10.1038/scibx.2012.718